Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis
نویسندگان
چکیده
منابع مشابه
Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis.
The vertebrate skeleton consists of over 200 individual bones, each with its own unique shape, size and function. We study the role of intrauterine muscle-induced mechanical loads in determining the three-dimensional morphology of developing bones. Analysis of the force-generating capacity of intrauterine muscles in mice revealed that developing bones are subjected to significant and progressiv...
متن کاملSmad4 Regulates Ureteral Smooth Muscle Cell Differentiation during Mouse Embryogenesis
Proper formation of ureteral smooth muscle cells (SMCs) during embryogenesis is essential for ureter peristalsis that propels urine from the kidney to the bladder in mammals. Currently the molecular factors that regulate differentiation of ureteral mesenchymal cells into SMCs are incompletely understood. A recent study has reported that Smad4 deficiency reduces the number of ureteral SMCs. Howe...
متن کاملDoes Central Fatigue Limit Muscle Force Generation Capacity during Fatigue?
There is general agreement on peripheral factors of muscle fatigue that develop within the muscle and impair muscle fiber contractile mechanisms and muscle performance. Central factors of muscle fatigue that arise within the central nervous system have also been suggested to influence muscle force during fatigue. However, no direct empirical evidence of their influence on muscle force capacity ...
متن کاملOptimal Trajectory of Flexible Manipulator with Maximum Load Carrying Capacity
In this paper, a new formulation along with numerical solution for the problem of finding a point-to-point trajectory with maximum load carrying capacities for flexible manipulators is proposed. For rigid manipulators, the major limiting factor in determining the Dynamic Load Carrying Capacity (DLCC) is the joint actuator capacity. The flexibility exhibited by light weight robots or by robots o...
متن کاملDevelopment of Composite Scaffolds for Load-Bearing Segmental Bone Defects
The need for a suitable tissue-engineered scaffold that can be used to heal load-bearing segmental bone defects (SBDs) is both immediate and increasing. During the past 30 years, various ceramic and polymer scaffolds have been investigated for this application. More recently, while composite scaffolds built using a combination of ceramics and polymeric materials are being investigated in a grea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2011
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.063768